This issue isn't much different for any visual artist today. With POD sites like FAA that buyers choose sizes and configurations (substrate, framing, etc) on an individual basis.
The issue becomes what's the market for OE custom work? I don't think there is one. You can't be cheaper than what they can order online because of upfront costs. It's no difference of product than what can be ordered and it's 'used'.
So first I think you have to make these different prints than your OE prints; I call them artists prints or proofs and provide COA and other artist done enhancements.
Then I'm testing art rotation services for exhibit spaces. Instead of corps being at the whim of desperate artists they can turn their exhibit area into the motivational purpose it was intended for. Art affects behavior. This way I can have at least cost recovery on custom work, and the business gets art that's helping them. Besides the delegation of scheduling, hanging and maintaining the exhibit.
-- mary ellen anderson