If you like it, "like" it.
If you have something to say about it, "comment".
If it's one of your favorites, "favorite" it.
And if you're a group admin and feel it exemplifies what your group is about, "feature" it.
If you're featured, say thank you.
It's not spamming to reply, and I think it's good manners if you have the time, even though most commenters never come back to see if you did or not.
Just don't post links to your artwork in the comment section of someone else's work. That's spamming. And tacky.