Imatinib In C-abl Kinase Domain, Model is a photograph by Scott Camazine which was uploaded on September 10th, 2015.
Imatinib In C-abl Kinase Domain, Model
Crystal structure of the c-abl kinase domain (cyan) in complex with imatinib (colored orange). Imatinib (Gleevec) blocks the activity of Abelson... more
Title
Imatinib In C-abl Kinase Domain, Model
Artist
Scott Camazine
Medium
Photograph
Description
Crystal structure of the c-abl kinase domain (cyan) in complex with imatinib (colored orange). Imatinib (Gleevec) blocks the activity of Abelson cytoplasmic tyrosine kinase (c-Abl), c-Kit and the platelet-derived growth factor receptor (PDGFR). As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans. Model based on Protein Database entry 1IEP.
Uploaded
September 10th, 2015
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